Turns out it is very,very real.
For years women have cried â€śman fluâ€ť when men make a fuss over a few sniffles.
But a new study suggests that men may actually suffer more when they are struck down with flu – because high levels of testosterone can weaken their immune response.
The study by Stanford University School of Medicine, examined the reactions of men and women to vaccination against flu.Â
It found women generally had a stronger antibody response to the jab than men, giving them better protection against the virus.
Men with lower testosterone levels also had a better immune response, more or less equivalent to that of women.
It has long been suggested that men might be more susceptible to bacterial, viral, fungal and parasitic infection than women are.
The study published in the Proceedings of the National Academy of Sciences, found women had higher blood levels of signaling proteins that immune cells pass back and forth, when the body is under threat.
Previous research has found that testosterone has anti-inflammatory properties, suggesting a possible interaction between the male sex hormone and immune response.
Professor of microbiology and immunology Mark Davis said: â€śThis is the first study to show an explicit correlation between testosterone levels, gene expression and immune responsiveness in humans.