Genetic disorders

What happens when cousins marry and breed?

In New Zealand we have laws that prevent same sex marriage, yet allow first cousins to marry. What are the odds of genetic mutation from first cousins marrying:

The inbreeding is computed as a percentage of chances for two alleles to be?identical by descent. This percentage is called “inbreeding coefficient“.

Ironically the inbreeding?coefficient?for first cousins is 6.25% which is probably the same percentage as there are homosexuals in society.

What are the issues of inbreeding then?

A 1998 review found 1-4% increased?morbidity?for offsprings of first cousins compared to offsprings of unrelated parents. A 1994 review found 4.4% increased?mortality?for offspring of first cousins. After controlling for several sociodemographic factors, infant mortality for offspring of first cousins had?odds ratios?of 1.36, 1.28, and 1.32 for the neonatal, postneonatal, and infant period. There has been little research on how inbreeding affects common adult disorder although some preliminary evidence support effects on many such disorders including cardiovascular diseases and common cancers. Many previously not identified genetic disorders have first been recognized in highly?endogamous?communities and the mutation causing the disease may be unique to such communities.

A review of 48 studies of children born to cousins found that most of the children were healthy, with birth defects affecting 4% of births for consanguineous couples compared to 2% for the general population.

So we have laws that allow first cousins to marry and as a result have an increased risk of genetic deformities and illness. None of this happens with sam sex marriage and yet that is prevented by law?

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How cool is this?

via Boing Boing

When Karen Bowersox?s granddaughter was born with?Down syndrome, she saw the challenges her mother faced trying to find clothes that fit her properly. After extensive research she still could not find any clothes made specifically for people with Down syndrome and so took matters into her own hands, launching her own fashion line Downs Designs.

The?story Bowersox tells on the Downs Designs site?of how all of this came together is really an interesting read.